A framework for oligonucleotide microarray preprocessing
نویسندگان
چکیده
منابع مشابه
Hands-On: A Framework for Oligonucleotide Microarrays Preprocessing
This document provides examples on the usage of the oligo package. The datasets used here can be downloaded by the user, who is expected to have the CEL and XYS files in the following directory structure: Directory Name Object Name Description expressionData affyExpressionFS Latin Square Affymetrix U95A exonData affyExonFS Exon Sample Dataset Human snpData affySnpFS HapMap samples on XBA Array ...
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Data preprocessing in microarray technology is a crucial initial step before data analysis is performed. Many preprocessing methods have been proposed but none has proved to be ideal to date. Frequently, datasets are limited by laboratory constraints so that the need is for guidelines on quality and robustness, to inform further experimentation while data are yet restricted. In this paper, we c...
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High-density oligonucleotide expression arrays are a widely used microarray platform. Affymetrix GeneChip arrays dominate this market. An important distinction between the GeneChip and other technologies is that on GeneChips, multiple short probes are used to measure gene expression levels. This makes preprocessing particularly important when using this platform. This chapter begins by describi...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btq431